Response to interleukin-4

Across TCGA patient cohorts, RNA activity of the Response to interleukin-4 pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are MEFV, CRTAM, and PTPN22, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-4 activity versus MEFV in GBM (Pearson r = 0.22).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	MEFV →	+0.626	+0.171	<.001	<.001	3	5
COAD	CRTAM →	+0.621	+0.142	<.001	.001	3	5
HNSC	PTPN22 →	+0.567	+0.153	.008	.004	3	4
LUAD	CLEC4D →	+0.529	+0.195	<.001	<.001	3	4
OV	SAA1 →	+1.657	+0.214	.008	<.001	3	4
GBM	JAK3 →	+1.047	+0.235	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070670 vs MEFV — GBM

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