Response to interleukin-4

Across TCGA cell cohorts, RNA activity of the Response to interleukin-4 pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are IL4R, NIPSNAP3B, and INPP5J, each associated with the pathway in up to 12 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-4 activity versus IL4R in BLOOD_Lymphoma (Pearson r = 0.52).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	IL4R →	+1.528	+0.142	<.001	<.001	3	12
KIDNEY	NIPSNAP3B →	-0.714	-0.152	.005	.001	3	12
BONE	INPP5J →	-1.211	-0.203	.004	<.001	3	10
LUNG_SCLC	TMCC2 →	-1.406	-0.086	.001	.003	3	10
BONE	GPLD1 →	-0.913	-0.217	<.001	<.001	3	9
BONE	ALDH5A1 →	-1.762	-0.209	<.001	.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070670 vs IL4R — BLOOD_Lymphoma

Explore this scatter interactively →