Response to interleukin-4

Across TCGA cell cohorts, RNA activity of the Response to interleukin-4 pathway is significantly associated with the RNA expression of multiple genes, with the SKIN cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CLEC11A, PODXL, and H2BC14, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Response to interleukin-4 activity versus CLEC11A in SKIN (Pearson r = -0.62).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CLEC11A →	-2.991	-0.310	.002	.003	3	3
BLOOD_Lymphoma	PODXL →	+2.059	+0.420	.009	<.001	3	3
BLOOD_Leukemia	H2BC14 →	+0.794	+0.627	<.001	.001	3	3
OESOPHAGUS	BTBD18 →	+0.097	+0.385	.002	.007	3	3
OESOPHAGUS	PDK3 →	+0.572	+0.522	.002	.001	3	3
STOMACH	NBPF9 →	+0.828	+0.312	.002	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070670 vs CLEC11A — SKIN

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