Positive regulation of leukocyte proliferation

Across TCGA patient cohorts, RNA activity of the Positive regulation of leukocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD33, LAIR1, and ITK, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of leukocyte proliferation activity versus CD33 in OV (Pearson r = 0.35).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	CD33 →	+0.631	+0.217	<.001	.001	3	10
LSCC	LAIR1 →	+0.943	+0.293	.001	.003	3	10
LSCC	ITK →	+1.046	+0.266	<.001	<.001	3	9
LSCC	ZNF831 →	+0.866	+0.260	<.001	<.001	3	9
LSCC	CD226 →	+0.801	+0.306	<.001	<.001	3	9
LSCC	SLA →	+1.108	+0.402	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070665 vs CD33 — OV

Explore this scatter interactively →