Negative regulation of leukocyte proliferation

Across TCGA cell cohorts, RNA activity of the Negative regulation of leukocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Lymphoma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TLN1, CYB5R3, and AKT3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of leukocyte proliferation activity versus TLN1 in BLOOD_Lymphoma (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TLN1 →	+0.702	+0.304	<.001	.003	3	5
SKIN	CYB5R3 →	+0.926	+0.316	.002	.001	3	5
BREAST	AKT3 →	+1.723	+0.573	.003	.002	3	4
PANCREAS	MAP2K2 →	+0.630	+0.640	.003	.005	3	4
OVARY	ELK3 →	+1.500	+0.321	.003	.001	3	4
OVARY	PRKCA →	+1.386	+0.257	.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070664 vs TLN1 — BLOOD_Lymphoma

Explore this scatter interactively →