Regulation of leukocyte proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte proliferation pathway is significantly associated with the shRNA dependency of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPPR1, SPRYD7, and H2AZ2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PLPPR1 grouped by Regulation of leukocyte proliferation-low versus -high activity in SOFT_TISSUE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	PLPPR1 →	-0.333	-0.128	.001	<.001	3	4
BREAST	SPRYD7 →	+0.136	+0.142	.004	.001	3	4
LUNG_NSCLC_LUSC	H2AZ2 →	-0.416	-0.183	.009	.005	3	4
SOFT_TISSUE	CCT7 →	+0.350	+0.141	.003	.006	3	3
OESOPHAGUS	TAS2R10 →	-0.285	-0.119	<.001	.001	3	3
OESOPHAGUS	NUFIP1 →	-0.311	-0.144	.007	.002	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PLPPR1 by Regulation of leukocyte proliferation activity — SOFT_TISSUE

Explore this box plot interactively →