Regulation of leukocyte proliferation

Across TCGA cell cohorts, RNA activity of the Regulation of leukocyte proliferation pathway is significantly associated with the RNA expression of multiple genes, with the OVARY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAB8B, CYB5R3, and TTLL1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of leukocyte proliferation activity versus RAB8B in OVARY (Pearson r = 0.54).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	RAB8B →	+1.292	+0.253	.001	.005	3	6
LUNG_SCLC	CYB5R3 →	+1.161	+0.273	<.001	.003	2	7
LUNG_SCLC	TTLL1 →	+0.966	+0.212	.004	.005	3	6
BLOOD_Lymphoma	CRAT →	+1.823	+0.172	.002	.007	3	5
OVARY	NEK1 →	+1.057	+0.304	.001	.001	3	5
BLOOD_Lymphoma	FBN1 →	+2.947	+0.242	.001	.003	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070663 vs RAB8B — OVARY

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