Protein modification by small protein removal

Across TCGA patient cohorts, RNA activity of the Protein modification by small protein removal pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are UCHL1, SULF1, and CACNA2D1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein modification by small protein removal activity versus UCHL1 in UCEC (Pearson r = 0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	UCHL1 →	+1.202	+0.076	<.001	.005	3	7
CCRCC	SULF1 →	+0.750	+0.031	.001	<.001	3	6
GBM	CACNA2D1 →	+0.617	+0.043	<.001	<.001	3	6
OV	RPL23A →	-0.543	-0.034	<.001	.008	3	5
GBM	RPL5 →	-0.261	-0.055	<.001	<.001	3	5
LSCC	SLC9A3R1_S269 →	-0.603	-0.029	.002	.006	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070646 vs UCHL1 — UCEC

Explore this scatter interactively →