Protein modification by small protein removal

Across TCGA patient cohorts, RNA activity of the Protein modification by small protein removal pathway is significantly associated with the RNA expression of multiple genes, with the BRCA cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EME1, DDIAS, and SMOC2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein modification by small protein removal activity versus EME1 in BRCA (Pearson r = 0.27).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	EME1 →	+0.813	+0.382	.003	.009	3	5
BRCA	DDIAS →	+1.031	+0.417	<.001	.005	3	5
HNSC	SMOC2 →	-1.173	-0.143	.003	<.001	3	5
OV	CDC25C →	+1.138	+0.222	<.001	<.001	2	5
OV	MAD2L1 →	+0.907	+0.184	.002	<.001	2	5
BRCA	CACNA1C-AS1 →	-0.359	-0.419	<.001	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070646 vs EME1 — BRCA

Explore this scatter interactively →