Protein modification by small protein removal

Across TCGA cell cohorts, RNA activity of the Protein modification by small protein removal pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CD58, C15orf48, and DUSP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, CD58 grouped by Protein modification by small protein removal-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	CD58 →	+0.992	+0.198	.008	<.001	3	4
PANCREAS	C15orf48 →	+3.503	+0.148	.002	.009	3	4
BONE	DUSP1 →	+2.650	+0.384	.005	.004	3	4
LIVER	TMEM165 →	+0.963	+0.199	<.001	.001	3	4
LIVER	RPS9 →	-0.620	-0.261	<.001	<.001	3	4
OESOPHAGUS	CYBRD1 →	-1.770	-0.132	.002	.003	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

CD58 by Protein modification by small protein removal activity — LIVER

Explore this box plot interactively →