Protein modification by small protein removal

Across TCGA cell cohorts, RNA activity of the Protein modification by small protein removal pathway is significantly associated with the shRNA dependency of multiple genes, with the PANCREAS cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TENT4A, MTNR1A, and NSMCE3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, TENT4A grouped by Protein modification by small protein removal-low versus -high activity in PANCREAS.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	TENT4A →	+0.177	+0.033	.002	.008	3	5
LUNG_SCLC	MTNR1A →	+0.225	+0.064	.001	.004	3	5
BLOOD_Myeloma	NSMCE3 →	+0.409	+0.076	<.001	<.001	3	4
SKIN	EPB41L1 →	+0.126	+0.021	.009	.001	3	4
SOFT_TISSUE	RPS6KB2 →	+0.282	+0.045	.003	.001	3	4
OESOPHAGUS	SCGB3A2 →	+0.217	+0.053	<.001	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

TENT4A by Protein modification by small protein removal activity — PANCREAS

Explore this box plot interactively →