Transepithelial transport

Across TCGA patient cohorts, RNA activity of the Transepithelial transport pathway is significantly associated with the RNA expression of multiple genes, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CA4, C18orf21, and SYBU, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transepithelial transport activity versus CA4 in PDAC (Pearson r = 0.26).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CA4 →	+0.690	+0.655	<.001	<.001	3	4
COAD	C18orf21 →	-0.330	-0.298	.005	.001	3	4
PDAC	SYBU →	+0.973	+0.808	<.001	<.001	3	4
COAD	PPM1M →	-0.502	-0.315	.007	<.001	3	4
GBM	GJB2 →	-1.246	-0.205	.001	.004	3	4
GBM	IKBIP →	-0.444	-0.228	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070633 vs CA4 — PDAC

Explore this scatter interactively →