Transepithelial transport

Across TCGA cell cohorts, RNA activity of the Transepithelial transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PNPT1, CSNK2B, and LRRC37A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PNPT1 grouped by Transepithelial transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	PNPT1 →	+0.758	+0.694	<.001	.003	3	5
SKIN	CSNK2B →	-0.380	-0.913	<.001	<.001	3	4
OESOPHAGUS	LRRC37A →	+0.647	+0.969	.002	.009	3	4
UPPER_AERODIGESTIVE_TRACT	CACFD1 →	+1.645	+1.222	.003	.004	3	3
UPPER_AERODIGESTIVE_TRACT	ACTL10 →	+0.638	+0.962	.003	.004	3	3
UPPER_AERODIGESTIVE_TRACT	SPTB →	+0.628	+0.970	.007	.004	2	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PNPT1 by Transepithelial transport activity — STOMACH

Explore this box plot interactively →