Transepithelial transport

Across TCGA cell cohorts, RNA activity of the Transepithelial transport pathway is significantly associated with the RNA expression of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SIAE, ZNF532, and RPL7A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Transepithelial transport activity versus SIAE in KIDNEY (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	SIAE →	-0.898	-0.359	.006	.004	3	5
PANCREAS	ZNF532 →	+1.168	+1.091	.002	.001	3	5
OESOPHAGUS	RPL7A →	-0.758	-1.436	.001	<.001	3	5
OESOPHAGUS	NMU →	+2.132	+1.064	.001	.004	3	4
OESOPHAGUS	RAB11FIP5 →	-1.405	-1.823	<.001	<.001	3	4
KIDNEY	MEN1 →	-0.845	-0.359	.004	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070633 vs SIAE — KIDNEY

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