Regulation of centromeric sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Regulation of centromeric sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are POGLUT2, ANKRD54, and PIP4K2B, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, POGLUT2 grouped by Regulation of centromeric sister chromatid cohesion-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	POGLUT2 →	-2.006	-0.186	.007	.009	3	4
PANCREAS	ANKRD54 →	-0.710	-0.138	<.001	.003	3	4
PANCREAS	PIP4K2B →	-0.819	-0.136	<.001	.001	3	4
BLOOD_Myeloma	KIAA0100 →	-0.946	-0.276	.001	.002	3	4
BLOOD_Myeloma	MAP4K2 →	-0.868	-0.209	.007	<.001	3	4
BLOOD_Myeloma	ZNRF3 →	-0.980	-0.262	.004	.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

POGLUT2 by Regulation of centromeric sister chromatid cohesion activity — BLOOD_Leukemia

Explore this box plot interactively →