Regulation of centromeric sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Regulation of centromeric sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the SOFT_TISSUE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RPL26, HNRNPA1, and CELF4, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of centromeric sister chromatid cohesion activity versus RPL26 in SOFT_TISSUE (Pearson r = -0.58).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	RPL26 →	-0.718	-1.453	<.001	.003	3	4
URINARY_TRACT	HNRNPA1 →	+0.665	+0.233	<.001	.006	3	4
LUNG_NSCLC_LUAD	CELF4 →	+0.712	+0.597	.001	.009	3	4
BLOOD_Lymphoma	COMMD1 →	-0.731	-0.841	.003	.009	3	4
SOFT_TISSUE	LRRC14 →	+0.942	+1.304	.001	<.001	3	3
LARGE_INTESTINE	SEMA3G →	+0.598	+0.157	.005	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070602 vs RPL26 — SOFT_TISSUE

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