Centromeric sister chromatid cohesion

Across TCGA cell cohorts, RNA activity of the Centromeric sister chromatid cohesion pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PLPPR2, ARSB, and TENT5A, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Centromeric sister chromatid cohesion activity versus PLPPR2 in BLOOD_Leukemia (Pearson r = 0.41).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PLPPR2 →	+1.433	+0.175	.006	.001	3	5
URINARY_TRACT	ARSB →	+0.837	+0.517	.005	.002	3	4
LIVER	TENT5A →	+2.260	+0.406	.001	<.001	3	3
BLOOD_Leukemia	BUB1B →	-0.778	-0.173	.007	<.001	3	3
BLOOD_Leukemia	DTX3L →	-0.659	-0.126	<.001	.002	3	3
BLOOD_Leukemia	HEG1 →	-0.828	-0.131	.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070601 vs PLPPR2 — BLOOD_Leukemia

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