Cell-cell adhesion involved in gastrulation

pathway activity — cross-omics
GO:0070586Cross-omicsRNA → PROTEIN-MSPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cell-cell adhesion involved in gastrulation pathway is significantly associated with the protein abundance of multiple proteins, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are ANXA2, GTF3C2_S167, and AHNAK_S5780, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner proteinX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMANXA2 →+0.657+0.097<.001<.00138
COADGTF3C2_S167 →-0.318-0.035<.001.00136
UCECAHNAK_S5780 →+0.761+0.074<.001.00435
UCECAHNAK2_S3408 →+1.186+0.080<.001<.00135
LUADAHNAK_T490 →+0.587+0.054<.001.00135
OVRBBP6_S873 →-0.525-0.039.009.00535
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration