Cell-cell adhesion involved in gastrulation

pathway activity — cross-omics
GO:0070586Cross-omicsPROTEIN-MS → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, RNA activity of the Cell-cell adhesion involved in gastrulation pathway is significantly associated with the RNA expression of multiple genes, with the GBM cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are HEBP1, GBGT1, and IRF5, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
GBMHEBP1 →+0.415+0.335.003<.00134
PDACGBGT1 →+0.247+0.740.009.00234
GBMIRF5 →+0.476+0.326.005<.00134
GBMIL18 →+0.674+0.308.003<.00134
GBMSLC8B1 →+0.313+0.294.009.00134
LSCCKIF7 →-0.585-0.419.001.00634
Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

Exploration