Protein localization to mitochondrion

Across TCGA patient cohorts, RNA activity of the Protein localization to mitochondrion pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TXNDC5, MAP9, and PHRF1_S814, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to mitochondrion activity versus TXNDC5 in CCRCC (Pearson r = -0.37).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	TXNDC5 →	-0.271	-0.014	.003	.008	3	4
CCRCC	MAP9 →	+0.502	+0.029	.003	<.001	3	4
CCRCC	PHRF1_S814 →	-0.448	-0.020	.002	.007	3	4
HNSC	SND1_S645 →	-0.596	-0.070	.002	.004	3	4
GBM	AKAP13_S2498 →	-0.441	-0.029	.003	.002	2	5
PDAC	MAP2_S1480 →	+0.885	+0.025	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070585 vs TXNDC5 — CCRCC

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