Protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RAC2, TLCD1, and GBP2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RAC2 grouped by Protein localization to mitochondrion-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RAC2 →	-2.812	-0.144	.001	.007	3	4
LUNG_NSCLC_LUSC	TLCD1 →	+1.113	+0.233	<.001	.007	2	5
LUNG_NSCLC_LUSC	GBP2 →	-1.903	-0.451	.005	<.001	3	4
BREAST	EFHD1 →	+1.931	+0.154	.004	.003	3	4
BREAST	MCF2L →	+1.811	+0.186	.003	.001	3	4
BLOOD_Leukemia	POMT1 →	+0.789	+0.193	.007	.009	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RAC2 by Protein localization to mitochondrion activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →