Protein localization to mitochondrion

Across TCGA cell cohorts, RNA activity of the Protein localization to mitochondrion pathway is significantly associated with the RNA expression of multiple genes, with the UPPER_AERODIGESTIVE_TRACT cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TPM1, LAPTM4B, and HMGB2, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein localization to mitochondrion activity versus TPM1 in UPPER_AERODIGESTIVE_TRACT (Pearson r = -0.66).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TPM1 →	-1.394	-0.166	.001	<.001	3	4
BLOOD_Leukemia	LAPTM4B →	+3.582	+0.136	<.001	.003	3	4
BLOOD_Leukemia	HMGB2 →	-0.625	-0.126	.003	.001	3	4
BLOOD_Leukemia	RAC3 →	+1.333	+0.138	<.001	<.001	3	4
SKIN	NAT8L →	+1.856	+0.204	<.001	<.001	3	4
LUNG_SCLC	SRSF5 →	-0.645	-0.179	.005	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070585 vs TPM1 — UPPER_AERODIGESTIVE_TRACT

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