Cadmium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Cadmium ion transmembrane transport pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are MMP8, MMP9, and PRAM1_S204, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cadmium ion transmembrane transport activity versus MMP8 in PDAC (Pearson r = 0.44).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	MMP8 →	+1.312	+0.102	<.001	<.001	3	7
GBM	MMP9 →	+1.119	+0.134	<.001	<.001	3	7
BRCA	PRAM1_S204 →	+1.048	+0.095	.001	.002	3	7
GBM	BPI →	+1.607	+0.183	<.001	<.001	3	7
GBM	PRTN3 →	+1.208	+0.132	<.001	<.001	3	7
PDAC	RNASE3 →	+1.343	+0.117	<.001	<.001	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070574 vs MMP8 — PDAC

Explore this scatter interactively →