Cadmium ion transmembrane transport

Across TCGA patient cohorts, RNA activity of the Cadmium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are NPAT, HEPACAM, and RNA5SP493, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Cadmium ion transmembrane transport activity versus NPAT in UCEC (Pearson r = -0.31).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	NPAT →	-0.381	-0.798	.001	.001	3	4
PDAC	HEPACAM →	-0.066	-0.249	<.001	.008	3	3
PDAC	RNA5SP493 →	-0.466	-0.240	.003	.007	3	3
PDAC	ADSS2 →	-0.249	-0.215	.001	.001	3	3
GBM	SPINT5P →	-0.501	-0.731	.004	<.001	3	3
GBM	SLC12A9-AS1 →	-0.376	-0.562	.003	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070574 vs NPAT — UCEC

Explore this scatter interactively →