Cadmium ion transmembrane transport

Across TCGA cell cohorts, RNA activity of the Cadmium ion transmembrane transport pathway is significantly associated with the RNA expression of multiple genes, with the STOMACH cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are WDR26, ZSCAN21, and ZNF256, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, WDR26 grouped by Cadmium ion transmembrane transport-low versus -high activity in STOMACH.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	WDR26 →	+1.133	+1.483	.001	.001	3	4
LUNG_NSCLC_LUAD	ZSCAN21 →	+0.559	+0.938	.008	.001	3	4
UPPER_AERODIGESTIVE_TRACT	ZNF256 →	+1.615	+1.251	.001	<.001	3	4
CNS	PEX13 →	+0.331	+0.902	.006	.007	3	4
BLOOD_Leukemia	ABHD17C →	-1.355	-0.929	.005	.001	3	4
KIDNEY	LARGE1 →	+1.187	+1.016	.008	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

WDR26 by Cadmium ion transmembrane transport activity — STOMACH

Explore this box plot interactively →