Positive regulation of neuron projection regeneration

Across TCGA patient cohorts, RNA activity of the Positive regulation of neuron projection regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are KANK2_S375, CNRIP1, and DNMT1_S714, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of neuron projection regeneration activity versus KANK2_S375 in CCRCC (Pearson r = 0.53).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	KANK2_S375 →	+0.514	+0.083	<.001	<.001	3	8
UCEC	CNRIP1 →	+0.836	+0.091	<.001	.001	3	7
LSCC	DNMT1_S714 →	-0.614	-0.070	.001	<.001	3	7
UCEC	EHD2 →	+0.778	+0.082	<.001	.001	3	7
UCEC	CAV1 →	+0.717	+0.093	<.001	.002	3	7
UCEC	CAVIN1 →	+0.739	+0.072	.001	.006	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070572 vs KANK2_S375 — CCRCC

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