Positive regulation of neuron projection regeneration

Across TCGA cell cohorts, RNA activity of the Positive regulation of neuron projection regeneration pathway is significantly associated with the shRNA dependency of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PTN, IGF1R, and STK24, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PTN grouped by Positive regulation of neuron projection regeneration-low versus -high activity in BREAST.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	PTN →	-0.166	-1.284	<.001	<.001	3	9
LARGE_INTESTINE	IGF1R →	-0.387	-1.189	.001	<.001	3	6
BREAST	STK24 →	-0.257	-1.071	<.001	<.001	3	6
UPPER_AERODIGESTIVE_TRACT	FKBP1B →	-0.409	-1.712	<.001	<.001	3	5
BONE	STX8 →	-0.336	-1.910	.004	<.001	3	4
BONE	LCN12 →	-0.282	-1.862	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PTN by Positive regulation of neuron projection regeneration activity — BREAST

Explore this box plot interactively →