Negative regulation of neuron projection regeneration

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuron projection regeneration pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are CNPY4, COL3A1, and SP110, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron projection regeneration activity versus CNPY4 in PDAC (Pearson r = 0.29).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	CNPY4 →	+0.244	+0.050	.005	.006	3	6
OV	COL3A1 →	+0.445	+0.038	.001	.002	3	6
BRCA	SP110 →	-0.415	-0.043	.003	<.001	3	5
BRCA	SP110_S244 →	-0.344	-0.025	<.001	.001	3	5
PDAC	CRTAP →	+0.383	+0.052	.003	.001	3	5
UCEC	RCN2 →	+0.404	+0.092	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070571 vs CNPY4 — PDAC

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