Negative regulation of neuron projection regeneration

Across TCGA patient cohorts, RNA activity of the Negative regulation of neuron projection regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SPP1, P4HA1, and CTSL, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron projection regeneration activity versus SPP1 in LUAD (Pearson r = 0.43).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	SPP1 →	+1.551	+1.117	<.001	<.001	3	8
PDAC	P4HA1 →	+0.699	+0.700	<.001	<.001	3	6
GBM	CTSL →	+0.694	+0.340	<.001	<.001	3	6
GBM	CD300A →	+0.523	+0.261	.002	.001	3	6
PDAC	CLDN14 →	+0.434	+0.538	.003	.007	3	6
CCRCC	CTSB →	+0.629	+0.328	.002	.005	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070571 vs SPP1 — LUAD

Explore this scatter interactively →