Negative regulation of neuron projection regeneration

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron projection regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are ZBED4, MBNL1, and ZNF670, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, ZBED4 grouped by Negative regulation of neuron projection regeneration-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	ZBED4 →	+0.821	+1.524	<.001	<.001	3	6
LUNG_SCLC	MBNL1 →	-1.377	-1.406	.001	.002	3	5
SOFT_TISSUE	ZNF670 →	+0.611	+1.339	.003	.007	3	5
LIVER	STX1A →	-1.630	-1.955	.001	<.001	3	5
LUNG_SCLC	CCNJ →	+1.265	+1.342	.004	.001	3	4
LUNG_SCLC	KAT14 →	+0.752	+1.540	.006	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

ZBED4 by Negative regulation of neuron projection regeneration activity — LUNG_SCLC

Explore this box plot interactively →