Negative regulation of neuron projection regeneration

Across TCGA cell cohorts, RNA activity of the Negative regulation of neuron projection regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PRUNE1, EHBP1L1, and CDC42SE1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Negative regulation of neuron projection regeneration activity versus PRUNE1 in BLOOD_Myeloma (Pearson r = 0.88).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PRUNE1 →	+1.049	+0.430	.001	<.001	3	4
LUNG_SCLC	EHBP1L1 →	+1.852	+1.163	.001	<.001	2	4
BLOOD_Lymphoma	CDC42SE1 →	+1.036	+0.213	.001	.002	3	3
OVARY	VPS72 →	+0.948	+0.481	<.001	.009	3	3
BLOOD_Myeloma	TRAFD1 →	+0.780	+0.362	.005	.001	3	3
BLOOD_Myeloma	DLGAP4 →	+0.919	+0.335	.008	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070571 vs PRUNE1 — BLOOD_Myeloma

Explore this scatter interactively →