Regulation of neuron projection regeneration

Across TCGA cell cohorts, RNA activity of the Regulation of neuron projection regeneration pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_NSCLC_LUAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PYGO2, SERPINE1, and STK35, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, PYGO2 grouped by Regulation of neuron projection regeneration-low versus -high activity in LUNG_NSCLC_LUAD.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	PYGO2 →	+0.631	+0.825	<.001	.001	3	5
SOFT_TISSUE	SERPINE1 →	-3.610	-1.189	<.001	.001	3	5
LUNG_SCLC	STK35 →	+0.778	+1.248	.003	.004	2	6
STOMACH	PRR14L →	+0.666	+1.051	.003	.004	3	5
URINARY_TRACT	AUTS2 →	+2.333	+1.881	<.001	.002	3	4
SOFT_TISSUE	ADGRG1 →	-4.141	-1.806	.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

PYGO2 by Regulation of neuron projection regeneration activity — LUNG_NSCLC_LUAD

Explore this box plot interactively →