Regulation of neuron projection regeneration

Across TCGA cell cohorts, RNA activity of the Regulation of neuron projection regeneration pathway is significantly associated with the RNA expression of multiple genes, with the BONE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are METTL18, CCZ1B, and TPRG1L, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of neuron projection regeneration activity versus METTL18 in BONE (Pearson r = 0.70).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	METTL18 →	+0.801	+0.319	<.001	.001	3	5
SKIN	CCZ1B →	+0.920	+0.825	<.001	.004	3	4
BLOOD_Lymphoma	TPRG1L →	+0.671	+0.630	.005	.008	3	4
LUNG_NSCLC_LUAD	NOL11 →	+0.495	+0.550	<.001	.002	3	3
BLOOD_Lymphoma	VPS45 →	+0.973	+0.943	<.001	.006	3	3
LUNG_NSCLC_LUAD	COA6 →	+0.805	+0.684	.005	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070570 vs METTL18 — BONE

Explore this scatter interactively →