Positive regulation of vitamin D receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Positive regulation of vitamin D receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the PDAC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SHROOM3_S439, BICD2, and ZNF608_T481, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Positive regulation of vitamin D receptor signaling pathway activity versus SHROOM3_S439 in PDAC (Pearson r = -0.35).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PDAC	SHROOM3_S439 →	-0.613	-0.056	<.001	.001	3	5
LSCC	BICD2 →	+0.429	+0.072	.002	.001	3	5
OV	ZNF608_T481 →	-0.531	-0.051	<.001	.006	3	4
LSCC	EGFR →	+0.610	+0.053	<.001	.001	3	4
LSCC	HID1 →	-0.378	-0.078	.005	.001	3	4
HNSC	TNKS1BP1_S920 →	+0.359	+0.073	.007	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070564 vs SHROOM3_S439 — PDAC

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