Regulation of vitamin D receptor signaling pathway

Across TCGA patient cohorts, RNA activity of the Regulation of vitamin D receptor signaling pathway pathway is significantly associated with the protein abundance of multiple proteins, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are TLN1, SPARC, and ACTN1, each associated with the pathway in up to 7 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vitamin D receptor signaling pathway activity versus TLN1 in OV (Pearson r = 0.38).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	TLN1 →	+0.352	+0.064	<.001	<.001	3	7
OV	SPARC →	+0.637	+0.054	<.001	<.001	3	7
UCEC	ACTN1 →	+0.775	+0.070	<.001	<.001	3	7
OV	DAPK3 →	+0.411	+0.050	<.001	.001	3	7
OV	FHL3 →	+0.798	+0.064	<.001	<.001	3	7
BRCA	SERPINH1 →	+0.497	+0.040	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070562 vs TLN1 — OV

Explore this scatter interactively →