Regulation of vitamin D receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of vitamin D receptor signaling pathway pathway is significantly associated with the shRNA dependency of multiple genes, with the LARGE_INTESTINE cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF3A, PFKFB3, and SLC9A6, each associated with the pathway in up to 3 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, KIF3A grouped by Regulation of vitamin D receptor signaling pathway-low versus -high activity in LARGE_INTESTINE.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	KIF3A →	-0.255	-0.193	.001	.005	3	2
LARGE_INTESTINE	PFKFB3 →	-0.126	-0.193	.003	.005	3	2
LARGE_INTESTINE	SLC9A6 →	-0.307	-0.193	<.001	.005	3	2
LARGE_INTESTINE	PCDHA12 →	-0.425	-0.153	.009	.007	3	2
CNS	KCTD10 →	-0.240	-0.266	<.001	.001	3	2
BREAST	PLBD2 →	-0.139	-0.341	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

KIF3A by Regulation of vitamin D receptor signaling pathway activity — LARGE_INTESTINE

Explore this box plot interactively →