Regulation of vitamin D receptor signaling pathway

Across TCGA cell cohorts, RNA activity of the Regulation of vitamin D receptor signaling pathway pathway is significantly associated with the RNA expression of multiple genes, with the BREAST cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are C20orf144, TCF4, and CCDC3, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Regulation of vitamin D receptor signaling pathway activity versus C20orf144 in BREAST (Pearson r = -0.63).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	C20orf144 →	-0.505	-0.394	<.001	<.001	3	4
OESOPHAGUS	TCF4 →	+1.733	+0.198	.005	.005	3	3
OESOPHAGUS	CCDC3 →	+1.640	+0.189	.005	.009	3	3
CNS	DNAI4 →	-1.551	-0.541	.002	.002	3	3
BREAST	NUTM2G →	-0.474	-0.387	.003	<.001	3	3
PANCREAS	CLN5 →	-0.873	-0.229	.001	.009	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070562 vs C20orf144 — BREAST

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