Protein K63-linked ubiquitination

Across TCGA patient cohorts, RNA activity of the Protein K63-linked ubiquitination pathway is significantly associated with the RNA expression of multiple genes, with the COAD cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are PSME2P2, CEP68, and AFF3, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein K63-linked ubiquitination activity versus PSME2P2 in COAD (Pearson r = 0.17).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	PSME2P2 →	+0.740	+0.453	<.001	.003	3	5
BRCA	CEP68 →	-0.367	-0.152	.009	.001	2	5
GBM	AFF3 →	-0.734	-0.167	.004	<.001	3	4
OV	LINC00667 →	-0.563	-0.576	.004	.002	3	4
LSCC	IFNG →	+0.821	+0.317	<.001	.007	3	4
COAD	KIF3B →	-0.384	-0.449	.002	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070534 vs PSME2P2 — COAD

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