Protein K63-linked ubiquitination

Across TCGA cell cohorts, RNA activity of the Protein K63-linked ubiquitination pathway is significantly associated with the shRNA dependency of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DPEP2, PAK1IP1, and RHCE, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DPEP2 grouped by Protein K63-linked ubiquitination-low versus -high activity in BLOOD_Leukemia.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	DPEP2 →	-0.186	-0.041	.003	.001	3	5
BLOOD_Myeloma	PAK1IP1 →	-0.370	-0.043	.004	.001	3	5
LARGE_INTESTINE	RHCE →	-0.130	-0.069	.002	.003	3	5
LUNG_NSCLC_LUSC	CPXM1 →	-0.385	-0.087	.002	.005	3	5
CNS	RPP40 →	-0.313	-0.062	.006	.001	3	5
UPPER_AERODIGESTIVE_TRACT	DDX25 →	+0.175	+0.060	.008	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DPEP2 by Protein K63-linked ubiquitination activity — BLOOD_Leukemia

Explore this box plot interactively →