Protein kinase C signaling

Across TCGA patient cohorts, RNA activity of the Protein kinase C signaling pathway is significantly associated with the protein abundance of multiple proteins, with the CCRCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SERPINF2, HSPG2, and SERPING1, each associated with the pathway in up to 8 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein kinase C signaling activity versus SERPINF2 in CCRCC (Pearson r = 0.21).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	SERPINF2 →	+0.590	+0.056	<.001	<.001	3	8
OV	HSPG2 →	+0.473	+0.035	<.001	.001	3	8
CCRCC	SERPING1 →	+0.684	+0.057	<.001	<.001	3	7
BRCA	SSC5D →	+0.869	+0.032	<.001	<.001	3	7
CCRCC	C7 →	+0.554	+0.044	.003	.002	3	7
CCRCC	F13A1 →	+0.604	+0.044	.003	.003	3	7

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070528 vs SERPINF2 — CCRCC

Explore this scatter interactively →