Protein kinase C signaling

Across TCGA patient cohorts, RNA activity of the Protein kinase C signaling pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are AKAP12, SRPX, and ASPA, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein kinase C signaling activity versus AKAP12 in OV (Pearson r = -0.09).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	AKAP12 →	+1.292	+0.691	.001	.003	3	9
UCEC	SRPX →	+1.363	+0.996	<.001	<.001	3	8
HNSC	ASPA →	+0.633	+0.819	<.001	<.001	3	8
HNSC	MGP →	+1.389	+0.834	<.001	<.001	3	8
COAD	C7 →	+1.687	+0.770	<.001	.002	3	8
PDAC	SCN7A →	+1.167	+0.457	.001	.006	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070528 vs AKAP12 — OV

Explore this scatter interactively →