Protein kinase C signaling

Across TCGA patient cohorts, RNA activity of the Protein kinase C signaling pathway is significantly associated with the protein abundance of multiple proteins, with the UCEC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are AKAP12, AKAP12_S248, and AKAP12_S522, each associated with the pathway in up to 10 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein kinase C signaling activity versus AKAP12 in UCEC (Pearson r = 0.03).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	AKAP12 →	+1.042	+1.046	<.001	<.001	2	10
BRCA	AKAP12_S248 →	+0.736	+1.097	<.001	<.001	3	9
BRCA	AKAP12_S522 →	+1.838	+1.731	<.001	<.001	3	9
HNSC	AKAP12_S612 →	+1.102	+1.065	<.001	<.001	3	9
BRCA	AKAP12_S627 →	+0.959	+1.214	<.001	<.001	3	9
UCEC	AKAP12_S75 →	+0.688	+0.885	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070528 vs AKAP12 — UCEC

Explore this scatter interactively →