Protein kinase C signaling

Across TCGA cell cohorts, RNA activity of the Protein kinase C signaling pathway is significantly associated with the RNA expression of multiple genes, with the LIVER cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are DNAJC12, PLA2G6, and NR2C2AP, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, DNAJC12 grouped by Protein kinase C signaling-low versus -high activity in LIVER.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	DNAJC12 →	-2.742	-2.215	.008	<.001	2	5
OVARY	PLA2G6 →	-1.042	-0.791	.002	.006	3	4
LUNG_NSCLC_LUSC	NR2C2AP →	+1.003	+0.277	<.001	.001	3	4
LUNG_NSCLC_LUAD	ANO8 →	-0.557	-0.583	.008	.003	3	4
SKIN	INTS3 →	-0.651	-0.890	.001	.005	3	3
SKIN	DLGAP1 →	-1.830	-0.693	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

DNAJC12 by Protein kinase C signaling activity — LIVER

Explore this box plot interactively →