Protein kinase C signaling

Across TCGA cell cohorts, RNA activity of the Protein kinase C signaling pathway is significantly associated with the shRNA dependency of multiple genes, with the KIDNEY cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are RRP9, PCTP, and RND1, each associated with the pathway in up to 5 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, RRP9 grouped by Protein kinase C signaling-low versus -high activity in KIDNEY.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	RRP9 →	-0.343	-0.214	<.001	<.001	3	5
LUNG_SCLC	PCTP →	+0.181	+1.204	.003	.006	2	5
LUNG_SCLC	RND1 →	-0.272	-1.015	<.001	<.001	3	4
BONE	GRIK5 →	-0.231	-0.163	.003	.008	3	4
BLOOD_Leukemia	GBP4 →	-0.159	-0.274	<.001	.002	3	4
BLOOD_Leukemia	SEC62 →	-0.158	-0.127	<.001	.004	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

RRP9 by Protein kinase C signaling activity — KIDNEY

Explore this box plot interactively →