Protein kinase C signaling

Across TCGA cell cohorts, RNA activity of the Protein kinase C signaling pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Leukemia cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are TRAPPC6A, MEF2C, and FBXO24, each associated with the pathway in up to 2 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Protein kinase C signaling activity versus TRAPPC6A in BLOOD_Leukemia (Pearson r = 0.78).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	TRAPPC6A →	+1.630	+1.236	<.001	.003	3	1
BLOOD_Leukemia	MEF2C →	+2.960	+1.236	.002	.003	3	1
BLOOD_Leukemia	FBXO24 →	+1.270	+1.771	.008	<.001	3	1
BLOOD_Leukemia	BLVRA →	+2.964	+1.236	.001	.003	2	2
BLOOD_Leukemia	FBRSL1 →	-1.216	-1.907	.004	<.001	3	1
BLOOD_Leukemia	ATP6V1A →	+0.571	+1.208	.009	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070528 vs TRAPPC6A — BLOOD_Leukemia

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