Platelet aggregation

Across TCGA patient cohorts, RNA activity of the Platelet aggregation pathway is significantly associated with the RNA expression of multiple genes, with the OV cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are SFRP2, CXCL12, and MMP19, each associated with the pathway in up to 9 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, Platelet aggregation activity versus SFRP2 in OV (Pearson r = 0.28).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	SFRP2 →	+2.547	+0.197	.001	<.001	3	9
OV	CXCL12 →	+1.222	+0.182	.003	<.001	3	9
GBM	MMP19 →	+1.074	+0.137	<.001	<.001	3	9
UCEC	DIPK2B →	+0.557	+0.163	.005	.003	3	9
CCRCC	ADGRA2 →	+0.666	+0.252	<.001	<.001	3	9
BRCA	ANTXR1 →	+0.930	+0.209	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070527 vs SFRP2 — OV

Explore this scatter interactively →