Platelet aggregation

Across TCGA cell cohorts, RNA activity of the Platelet aggregation pathway is significantly associated with the RNA expression of multiple genes, with the LUNG_SCLC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are EP400, DTX3, and CFDP1, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The box plot shows the strongest association, EP400 grouped by Platelet aggregation-low versus -high activity in LUNG_SCLC.

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	EP400 →	-0.629	-0.325	.001	<.001	3	4
URINARY_TRACT	DTX3 →	-3.312	-0.568	.003	<.001	3	4
OESOPHAGUS	CFDP1 →	-0.767	-0.416	<.001	<.001	3	3
STOMACH	FOXRED2 →	-1.619	-0.451	.001	.006	3	3
STOMACH	CAV1 →	+4.023	+0.361	.005	.005	3	3
STOMACH	BCL2 →	-1.854	-0.375	.006	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

EP400 by Platelet aggregation activity — LUNG_SCLC

Explore this box plot interactively →