tRNA threonylcarbamoyladenosine metabolic process

Across TCGA patient cohorts, RNA activity of the tRNA threonylcarbamoyladenosine metabolic process pathway is significantly associated with the protein abundance of multiple proteins, with the LSCC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated proteins across cancer lineages are SSB, WDR75, and BRD8, each associated with the pathway in up to 6 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA threonylcarbamoyladenosine metabolic process activity versus SSB in LSCC (Pearson r = 0.11).

Pathway-associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	SSB →	+0.389	+0.075	<.001	<.001	3	6
OV	WDR75 →	+0.327	+0.031	.007	<.001	3	6
OV	BRD8 →	+0.211	+0.034	.001	.004	3	6
LSCC	ORC5 →	+0.379	+0.035	<.001	<.001	3	6
LSCC	SSRP1 →	+0.423	+0.054	<.001	.001	3	6
LSCC	CDC5L →	+0.191	+0.035	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070525 vs SSB — LSCC

Explore this scatter interactively →