tRNA threonylcarbamoyladenosine metabolic process

Across TCGA patient cohorts, RNA activity of the tRNA threonylcarbamoyladenosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the HNSC cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are CEP76, PSAT1, and CD302, each associated with the pathway in up to 4 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA threonylcarbamoyladenosine metabolic process activity versus CEP76 in HNSC (Pearson r = 0.19).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	CEP76 →	+0.497	+0.205	.002	<.001	3	4
LUAD	PSAT1 →	+0.853	+0.176	.001	<.001	3	4
OV	CD302 →	-0.616	-0.185	<.001	<.001	3	4
UCEC	RN7SL123P →	+0.502	+0.171	.001	.005	3	4
OV	DPH2 →	+0.379	+0.141	<.001	<.001	3	4
OV	CTSO →	-0.643	-0.111	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070525 vs CEP76 — HNSC

Explore this scatter interactively →