tRNA threonylcarbamoyladenosine metabolic process

Across TCGA cell cohorts, RNA activity of the tRNA threonylcarbamoyladenosine metabolic process pathway is significantly associated with the RNA expression of multiple genes, with the BLOOD_Myeloma cohort showing a particularly strong set of associations.

The most reproducible pathway-associated genes across cancer lineages are KIF3B, CD99L2, and ATP1A3, each associated with the pathway in up to 1 cancer types. Since the analysis shows associations rather than directional relationships, both pathway-to-partner and partner-to-pathway views are reported.

Each partner is linked to its corresponding Q-omics profile. The scatter plot shows the strongest association, tRNA threonylcarbamoyladenosine metabolic process activity versus KIF3B in BLOOD_Myeloma (Pearson r = -0.79).

Pathway-associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (pathway→partner) and Y-score (partner→pathway) are standardized regression coefficients; both directions are reported because the association is undirected. The reported p-values are derived from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	KIF3B →	-0.797	-1.603	.007	<.001	3	1
BLOOD_Myeloma	CD99L2 →	-0.792	-1.603	<.001	<.001	3	1
BLOOD_Myeloma	ATP1A3 →	+3.032	+1.603	.001	<.001	3	1
BLOOD_Myeloma	TWNK →	+0.975	+1.603	.003	<.001	3	1
BLOOD_Myeloma	GSG1 →	+0.036	+1.664	<.001	<.001	3	1
BLOOD_Myeloma	TXNDC15 →	-1.956	-1.749	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest associations by consensus.

GO:0070525 vs KIF3B — BLOOD_Myeloma

Explore this scatter interactively →